
马 强,医学博士,执业医师,副主任技师,硕士研究生导师
邮箱:maq705@nsmc.edu.cn
研究方向:恶性肿瘤发生发展的分子机制及小分子药物靶向治疗转化研究
个人简介
主要从事临床基础检验领域的临床、教学和科研工作,川北医学院“三全育人先进个人”、附属医院“青年新锐医师”,南充市职业健康专家。四川省医学传播学会医学检验发展与传播专委会副主任委员,四川省妇幼保健协会分子诊断及代谢组学专业委员会常务委员,南充市医学会检验专委会常务委员。主要从事临床基础检验工作,擅长临床检验质量管理和临床沟通。承担医学检验技术和临床医学本科生、研究生和留学生的《临床基础检验学技术》、《实验诊断学》、《医学检验专业英语》、《医学科研知识》等课程的教学任务。主要聚焦于恶性肿瘤发病机制及靶向治疗转化研究。主持四川省卫健委、四川省医学会、南充市科技局等各类课题7项,以(共同)第一作者或通讯作者在J Exp Clin Cancer Res、J Transl Med(2篇)、Chin Med、Eur J Pharm Sci、Cancer Sci、Front Pharmacol、J Cell Physiol、BMB Rep、中华医学遗传学等国际国内一流期刊发表研究论文20余篇(SCI收录期刊论文15篇,其中中科院一区和二区期刊论文5篇,单篇影响因子最高12.8,累计影响因子大于60)。Cancer Advances青年编委,Frontiers in Pharmacology、遵义医科大学学报等多本杂志审稿人。以主要完成人身份获四川省科技进步三等奖2项(2024年度,2019年度),获四川省医学会“优秀论文”和“青年优秀论文”各1篇(2023年,2022年)。
代表性课题
1. 四川省卫健委,17PJ588,二氢青蒿素抑制食管癌细胞增殖的分子机制研究,2017/01-2018/12,2万元,结题,主持
2. 四川省医学会,Q23047,二氢青蒿素通过下调COX-2表达抑制食管癌细胞增殖与转移的分子机制研究,2024-2026,2万元,结题,主持
3. 南充市科技局,22SXQT0001,RNA结合蛋白ZFP36L2促进胃癌生长与转移的分子机制研究,2022/09-2024/08,3万元,结题,主持
4. 南充市科技局,18SXHZ0579,二氢青蒿素通过下调hTERT表达介导食管癌转移抑制的分子机制,2018/12-2020/11,4万元,结题,主持
5. 川北医学院附属医院,23GC009(高层次人才科研启动基金),二氢青蒿素降解食管癌端粒重复序列结合因子2(TERF2)蛋白发挥抗肿瘤活性的分子机制,2023/09-2025/08,19万,在研,主持
代表性论文(10篇)
1. Ma Q#, Yang F#, Huang B, Pan X, Li W, Yu T, Wang X, Ran L, Qian K, Li H, Li H, Liu Y, Liang C, Ren J, Zhang Y, Wang S, Xiao B*. CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA-protein ternary complex. Journal of experimental & clinical cancer research, 2022, 41: 251.(中科院一区,IF2024=12.8)
2. Yang F#, Ma Q#, Huang B, Wang X, Pan X, Yu T, Ran L, Jiang S, Li H, Chen Y, Liu Y, Liang C, Ren J, Zhang Y, Wang S, Li W, Xiao B. CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability. Journal of translational medicine, 2023, 21: 402.(中科院二区,IF2024=7.5)
3. Ma Q, Yang F, Xiao B, Guo X*. Emerging roles of circular RNAs in tumorigenesis, progression, and treatment of gastric cancer. J Transl Med. 2024;22(1):207.(中科院二区,IF2024=7.5)
4. Ma Q#, Liao H#, Xu L, Li Q, Zou J, Sun R, Xiao D, Liu C, Pu W, Cai J, Zhou X, Huang G, Yao L, Zhong X, Guo X*. Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin. Chinese medicine, 2020, 15: 37.(中科院二区,IF2024=5.7)
5. Li Q#, Ma Q#, Xu L, Gao C, Yao L, Wen J, Yang M, Cheng J, Zhou X, Zou J, Zhong X*, Guo X*. Human Telomerase Reverse Transcriptase as a Therapeutic Target of Dihydroartemisinin for Esophageal Squamous Cancer. Front Pharmacol, 2021,12: 769787.(中科院三区,IF2024=4.8)
6. Liu X, Cheng J, Tang M, Liao C, Yang Y, Luo M, Xu L, Zhong X, Ma Q*, Guo X*. Exploring the Novel Role and Mechanistic Insights of Skeletal Muscle Relaxant Cyclobenzaprine Hydrochloride in Esophageal Squamous Cell Carcinoma Treatment. European Journal of Pharmaceutical Sciences, 2025:107051. (中科院三区,IF2024=4.7)
7. Li W#, Ma Q#, Wang X, Tang M, Lin J, Xiao B*. The characteristics of two patients coinfected with SARS-CoV-2 and HIV in Wuhan, China. Journal of medical virology, 2021, 93(1): 85-88.(中科院三区,IF2024=4.6)
8. Zou J#, Ma Q#, Gao C, Yang M, Wen J, Xu L, Guo X, Zhong X, Duan Y. WTAP promotes proliferation of esophageal squamous cell carcinoma via m(6)A-dependent epigenetic promoting of PTP4A1. Cancer science, 2024, 115(7): 2254-2268.(中科院二区,IF2024=4.3)
9. Ma Q#, Xu Y#, Liao H, Cai Y, Xu L, Xiao D, Liu C, Pu W, Zhong X*, Guo X*. Identification and validation of key genes associated with non-small-cell lung cancer. Journal of cellular physiology, 2019, 234 (12): 22742-22752.(中科院三区,IF2024=4.0)
10. Ma Q, Xu W, Guo X*. Pan cancer analysis of the oncogenic role of telomeric repeat binding factor 2 (TERF2) in human tumors and in vitro validation in gastric cancer by TERF2 knockdown. Discovery Oncology, 2025, 16: 234. (中科院四区,IF2024=2.9)