一、基础医学创新平台简介

    基础医学创新平台建筑面积1000余平方米，集中了基础医学院主要的大型科研仪器和实验设备，现有流式细胞仪、生化分析仪、蛋白质双向电泳系统、凝胶成像系统、荧光定量PCR仪等大型科研仪器50余台，资产800余万，是我校高坪校区唯一集科研、教学于一体的多功能平台。代谢病药物与生物制品南充市重点实验室和川北医学院大学生创新创业实践基地挂靠该平台开展工作，基础医学院教师及基础医学研究生主要依托该平台开展课题研究。同时，平台还针对临床医学本科学生开设了《分子医学技术》双创课程，大学生双创项目和开放性实验项目主要依托该平台完成。平台现设置有细胞实验室、分子生物学实验室、微生物实验室、免疫组化实验室、高分子材料合成室、毒物成瘾分析室、动物处理室、清洗消毒室等。

    创新平台集中了一批主要来自基础医学院的青年骨干，围绕动脉粥样硬化、肿瘤耐药、肿瘤靶向药物、肿瘤生物治疗、肿瘤代谢组学、生物医用材料等方向展开研究，取得了一系列研究成果和重要发现，近三年来以第一作者或通讯作者身份公开发表文章51篇，其中SCI收录30篇，中文核心期刊21篇。

二、近三年来承担的纵向课题  

三、近三年发表的代表性论文

1.Song YY (宋永砚), Zhao MY, Cheng X, Shen J, Khound R, Zhang KZ, Su QZ. CREBH mediates metabolic inflammation to hepatic VLDL overproduction and hyperlipoproteinemia. J Mol Med (Berl). 2017; 95(8): 839-849.

2.Niu C, Luo Z, Yu L, Yang Y, Chen Y, Luo X, Lai F, Song Y(宋永砚，通讯作者). Associations of the APOB rs693 and rs17240441 polymorphisms with plasma APOB and lipid levels: a meta-analysis.Lipids Health Dis. 2017; 16(1): 166.

3. Yanmei Wang, Zhan Lu, Jingxiao Zhang, Yang Yang, Jing Shen, Xiaoming Zhang,Yongyan Song (宋永砚，通讯作者). The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women. Lipids Health Dis. 2016; 15: 170.

4. Shujin Li, Yang Yang, Xiaoxiao Ouyang, Jing Shen, Min Zhou,Yongyan Song (宋永砚，通讯作者). Associations of the APOC3 rs2854116 and rs2854117 Polymorphisms with Plasma APOC3 and Lipid Levels: a Meta-Analysis. Int J Clin Exp Med. 2016; 9(8): 15972-15985.

5. Li Zhu, Zhan Lu, Liren Zhu, Xiaoxiao Ouyang, Yang Yang, Yanping Feng, Ping Li, Wenjing Ye, Xiaoming Zhang, Xiuyun Zhang,Yongyan Song (宋永砚，通讯作者). Plasma lipoprotein(a) levels are associated with the severity of coronary heart disease in Chinese Han people. Turk J Med Sci. 2016; 46(4): 1033-1041.

6.Yongyan Song (宋永砚), Yang Yang, Jingxiao Zhang, Yanmei Wang, Wenfeng He, Xiaoming Zhang, Jie Zhu, Zhan Lu. The apoB100/apoAI ratio is independently associated with the severity of coronary heart disease: a cross sectional study in patients undergoing coronary angiography. Lipids Health Dis. 2015; 14: 150.

7. Li Zhu, Zhan Lu, Liren Zhu, Xiaoxiao Ouyang, Yang Yang, Wenfeng He, Yanping Feng, Fang Yi,Yongyan Song (宋永砚，通讯作者). Lipoprotein ratios are better than conventional lipid parameters in predicting coronary heart disease in Chinese Han people. Kardiol Pol. 2015; 73(10): 723-730.

8.Yongyan Song (宋永砚), Liren Zhu, Mudwari Richa, Ping Li, Yang Yang, Suping Li. Associations of the APOC3 rs5128 polymorphism with plasma APOC3 and lipid levels: a meta-analysis. Lipids Health Dis. 2015; 14: 32.

9.Wenhu Liu (刘文虎), Jinxia Chang, Mingwei Liu, Jiangbei Yuan, Jinqiang Zhang, Jun Qin, Xuefeng Xia, Yi Wang. Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistance. Oncotarget. 2017, 8(28): 45793-45806.

10.Wenhu Liu（刘文虎）, Xiaojuan Guo, Qiang Li, Guang Xu, Mengpei Feng, Tianbing Guan, Leyu Yan, Wenna Nie, Tony Parker, Haitao Lv. Mass spectrometry based molecular profile dissects the complexity of traditional Chinese medicine. Anal. Methods. 2015, 7(7), 2902-2912.

11.Song G (宋桂芹), Liu K, Yang X, Mu B, Yang J, He L, Hu X, Li Q, Zhao Y, Cai X, Feng G. SATB1 plays an oncogenic role in esophageal cancer by up-regulation of FN1 and PDGFRB. Oncotarget. 2017; 8(11): 17771-17784.

12.Song G(宋桂芹), Liu K, Zhu X, Yang X, Shen Y, Wang W, Shi G, Li Q, Duan Y, Zhao Y, Feng G. The low IGFBP-3 level is associated with esophageal cancer patients: a meta-analysis. World J Surg Oncol. 2016; 14(1): 307

13.Jia Fei-yun (贾飞云), Ran Ming, Zhang Bo. Russian Journal of Physical Chemistry A. 2015(89)13:2393-2397.

14.Bing Wang (王冰), Jun Dong, Lijing Niu, Wenyan Chen, Dongliang Chen, Chengyi Shen, Jiang Zhu, Xiaoming Zhang. In vitro and in vivo degradation of potential anti-adhesion materials: Electrospun membranes of poly(ester-amide) based on L-phenylalanine and p-(dioxanone)，Journal of Biomedical Materials Research Part B. Applied Biomaterials. 2016; 105(6): 1369-1378.

15.Bing Wang (王冰), Chuan Chen, Chang Qiang Wu, Le Luo, Dong Liang Chen, Jun Dong, Jiang Zhu, Chengyi Shen, Xiao Ming Zhang. Analysis of the feasibility of Avrami equation to amino acid endcapped PPDO crystallization by using Malek and Mitsuhashi method. Crystal Research and Technology. 2016; 51(10): 569-574.

16.Jian-cai Tang (汤建才), An Rui, Yi-Qing Jiang,Jian Yang. Effects and mechanisms of metformin on the proliferation of Esophageal cancer cells in vitro and in vivo. Cancer research and treatments. 2017; 49(3): 778-789.

17.Jiang Z (蒋振), Shen H, Tang B, Yu Q, Ji X, Wang L. Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism mayserve as diagnostic markers for gastric cancer. Clin Chim Acta. 2017; 464: 148-154.

18.Yonggang Ren (任勇刚), Lu Qiu, Fenglin Lü, Xufang Ru, Shaojun Li, Yuancai Xiang, Siwang Yu, Yiguo Zhang. TALENs-directed knockout of the full-length transcription factor Nrf1αthat represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells. Sci. Rep. 2016; 6: 23775.