张红，医学博士，主管技师，硕士研究生导师
邮箱：redmaple7273@163.com
研究方向：病原体与宿主相互作用的分子机制研究及其转化应用
个人简介
四川省医学会检验专业委员会青年委员，四川省防痨协会结核病转化医学和临床试验专业委员会委员。川北医学院附属医院“青年新锐医师”，南充市职业健康专家。主要从事临床微生物检验相关的临床、教学和科研工作。先后承担《临床微生物学检验技术》、《实验诊断学》、《医学科研与创新实训》、《医学检验专业英语》等课程的理论和实验教学工作。主持/主研国家自然科学基金、南充市市校科技战略合作专项课题3项。以第一作者或通讯作者在《Experimental and Molecular Medicine》、《Molecular Therapy-Oncolytics》、《Infection and Immunity》、《Frontiers in Cellular and Infection Microbiology》、《BMC Microbiology》等杂志发表学术论文多篇。申请国家发明专利1项。
代表性课题
1. 国家自然科学基金青年科学基金项目：肺炎链球菌肽链内切酶 O(PepO)增强巨噬细胞吞噬功能的分子机制研究（2018.01-2020.12），项目编号81701572，项目负责人
2. 南充市市校科技战略合作项目：ΔA146Ply蛋白通过甘露糖受体发挥抗三阴性乳腺癌效应的分子机制研究（2021.08-2023.07），项目编号20SXQT0058，项目负责人
代表性论文（5篇）
1. Tao Zhu#; Hong Zhang#; Sijie Li; Kaifeng Wu; Yibing Yin; Xuemei Zhang ; Detoxified pneumolysin derivative ΔA146Ply inhibits autophagy and induces apoptosis in acute myeloid leukemia cells by activating mTOR signaling, Experimental & Molecular Medicine, 2022, 54(5): 601-612.
2. Hong Zhang#; Tao Zhu#; Ruoqiu Fu; Yang Peng; Peng Jing; Wenchun Xu; Hong Wang; Sijie Li; Zhaoche Shu; Yibing Yin; Xuemei Zhang ; Combination of Detoxified Pneumolysin Derivative DA146Ply and Berbamine as a Treatment Approach for Breast Cancer, Molecular Therapy-Oncolytics, 2020, 18: 247-261.
3. Sijie Li#; Hong Zhang#; Jiangming Xiao; Taixian Yuan; Zhaoche Shu; Yajun Min; Wenchun Xu; Yibing Yin; Xuemei Zhang ; Streptococcus pneumoniae Endopeptidase O Promotes the Clearance of Staphylococcus aureus and Streptococcus pneumoniae via SH2 Domain-Containing Inositol Phosphatase 1-Mediated Complement Receptor 3 Upregulation, Frontiers in Cellular and Infection Microbiology, 2020, 10: 358.
4. Jiaqiong Zou; Long Zhou; Chunlan Hu; Peng Jing; Xiaolan Guo; Sulan Liu; Yan Lei; Shangyu Yang; Jiankang Deng*; Hong Zhang* ; IL-8 and IP-10 expression from human bronchial epithelial cells BEAS-2B are promoted by Streptococcus pneumoniae endopeptidase O (PepO), BMC Microbiology, 2017, 17(1): 187.
5. Zhang Hong#; Kang Lihua#; Yao Hua; He Yujuan; Wang Xiaofang; Xu Wenchun; Song Zhixin; Yin Yibing; Zhang Xuemei ; Streptococcus pneumoniae EndopeptidaseO (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways, Frontiers in Cellular and Infection Microbiology, 2016, 6: 23.
